In heterogeneous catalysis, the catalyst is in a different phase from the reactants. SDS of cas: 7742-73-6, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 7742-73-6, name is 1,3-Dichloroisoquinoline. In an article，Which mentioned a new discovery about 7742-73-6
Under Pd(PPh3)4 catalysis, coupling of arylboronic acids to the 1-position of 1,3-dichloroisoquinoline takes place, leading exclusively to 1-aryl-3-chloroisoquinolines. This regiochemistry is demonstrated by the crystal structure of 3-chloro-1-(8-methoxy-1-naphthyl)isoquinoline. The 3-chloro group may be modified by nickel-catalysed reaction with Grignard reagents or direct nucleophilic displacement with LiSCH2Ph. Attempted lithiation of the 3-position is not successful (either deprotonation or complex reactivity results). Under zinc reduction in the presence of NiCl2-PPh3 and NaI, the 1-aryl-3-chloroisoquinolines furnish 3,3?-biisoquinolines in good yield.
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Reference：
Isoquinoline – Wikipedia,
Isoquinoline | C9H2528N – PubChem