Chemistry is traditionally divided into organic and inorganic chemistry. Recommanded Product: Isoquinoline-5-carbaldehyde, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 80278-67-7
Screening of library compounds has yielded pyrazolodiazepine derivatives with P2X7 receptor antagonist activity. To explore the structure-activity relationships (SAR) of these pyrazolodiazepines as human P2X7 receptor antagonists, derivatives were synthesized by substitutions at positions R2 and R3 of the pyrazolodiazepine skeleton. Using a 2?(3?)-O-(4-benzoylbenzoyl)ATP (BzATP)-induced fluorescent ethidium uptake assay, the activities of these derivatives were tested in HEK-293 cells stably expressing human P2X7 receptors. Moreover, the effect of these derivatives was assessed by measuring their effect on IL-1beta release induced by BzATP-induced activation of differentiated THP-1 cells. A 2-phenethyl pyrazolodiazepine derivative with a 1-methyl-1H-3-indolyl group at position R2 had fivefold greater activity than the derivative with a 5-isoquinolinyl at R2. Moreover, a benzyl moiety at R3 had fivefold greater activity than a bicyclic moiety. The stereochemical effect at C-6 showed a preference for the (R)-isomer. Among the series of active derivatives, compound 23b, with a phenethyl group at R1, a 3-methyl indole at R2, and a benzyl at R3, exhibited activity similar to that of the positive control, KN-62, as shown by the inhibitory effects of IL-1beta release.
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Reference：
Isoquinoline – Wikipedia,
Isoquinoline | C9H1009N – PubChem