With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1242157-15-8,6-Bromo-8-fluoro-3,4-dihydroisoquinolin-1(2H)-one,as a common compound, the synthetic route is as follows.
1242157-15-8, To a stirred solution of CD3OD (CAS 811-98-3; 3.1 mL, 76.2 mmol, 6 eq.) in THF (31 mL) at 0 C is added portionwise NaH (60% dipersion in mineral oil, 366 mg, 15.24 mmol, 1.2 eq.). The reaction mixture is stirred at 0 C for 20 min and 6-bromo-8-fluoro-3,4-dihydro-2H-isoquinolin-l-one (CAS 1242157-15-8, 3.1 g, 12.7 mmol, 1 eq.) is added in one portion. The reaction is stirred at RT for 1.5 h and NaH (60% dipersion in mineral oil, 60 mg, 2.5 mmol, 0.2 eq.) is added. The reaction mixture is stirred at RT for 18 h. The reaction mixture is quenched with a sat. NH4CI solution. THF is evaporated and water (31 mL) is added to the suspension.The suspension is stirred at RT for 1 h and then filtered. The solid is rinsed with water and dried under vacuum to afford the expected product.
The synthetic route of 1242157-15-8 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; GALAPAGOS NV; DESROY, Nicolas; JONCOUR, Agnes, Marie; PEIXOTO, Christophe; TEMAL-LAIB, Taoues; TIRERA, Amynata; BUCHER, Denis; AMANTINI, David; DE VOS, Steve, Irma, Joel; BRYS, Reginald, Christophe, Xavier; (396 pag.)WO2019/238424; (2019); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem