So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Ding, Lu; Gao, Run-Duo; You, Shu-Li researched the compound: Methyl 5-methoxyindole-2-carboxylate( cas:67929-86-6 ).Application of 67929-86-6.They published the article 《Palladium(0)-Catalyzed Intermolecular Asymmetric Cascade Dearomatization Reaction of Indoles with Propargyl Carbonate》 about this compound( cas:67929-86-6 ) in Chemistry – A European Journal. Keywords: alkylindolyl methyl malonate preparation propargyl carbonate palladium tandem dearomatization; alkyl methylene dihydrocarbazole dicarboxylate chemoselective regioselective enantioselective preparation; allylic compounds; asymmetric catalysis; cascade reactions; dearomatization; palladium. We’ll tell you more about this compound (cas:67929-86-6).
An intermol. asym. cascade dearomatization reaction of indole derivatives with propargyl carbonate was developed. The challenges associated with both the chemoselectivity between the carbon and nitrogen nucleophile and the enantioselective control during the formation of an all-carbon quaternary stereogenic center were well addressed by a Pd catalytic system derived from the Feringa ligand. A series of enantioenriched multiply substituted fused indolenines were provided in good yields (71-86%) with excellent enantioselectivity (91-96% ee) and chemoselectivity (3/4>19:1 in most cases).
When you point to this article, it is believed that you are also very interested in this compound(67929-86-6)Application of 67929-86-6 and due to space limitations, I can only present the most important information.
Reference:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem