Product Details of 67929-86-6. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: Methyl 5-methoxyindole-2-carboxylate, is researched, Molecular C11H11NO3, CAS is 67929-86-6, about Synthesis of indolylalkoxyiminoalkylcarboxylates as leukotriene biosynthesis inhibitors.
A series of substituted indolylalkoxyiminoalkylcarboxylates, e.g., I (R1 = 2-quinolinyl, 2-pyridyl, 4-thiazolyl, 2-benzothiazolyl, R2 = CH2ON:CHCO2H, CH2ON:CMeCO2H), were found to be potent leukotriene biosynthesis inhibitors. The structure-activity relationships were investigated. Representative potent inhibitors identified were the quinolyl I (R1 = 2-quinolinyl, R2 = CH2ON:CHCO2H ) (A-86885) and pyridyl I (R1 = 2-pyridyl, R2 = R2 = CH2ON:CHCO2H) (A-86886) congeners with in vitro IC50s of 21 and 9 nM and in vivo leukotriene inhibition in the rat with oral ED50s of 0.9 and 1.7 mg/kg, resp.
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Reference:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem