So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Coluccia, Antonio; Puxeddu, Michela; Nalli, Marianna; Wei, Chih-Ku; Wu, Yu-Hsuan; Mastrangelo, Eloise; Mohmmed, Tasneem; Tarantino, Delia; Bugert, Joachim Jakob; Schreiner, Benno; Nolte, Juliane; Schwarze, Frank; La Regina, Giuseppe; Lee, Jin-Ching; Silvestri, Romano researched the compound: Methyl 5-methoxyindole-2-carboxylate( cas:67929-86-6 ).Related Products of 67929-86-6.They published the article 《Discovery of Zika Virus NS2B/NS3 Inhibitors That Prevent Mice from Life-Threatening Infection and Brain Damage》 about this compound( cas:67929-86-6 ) in ACS Medicinal Chemistry Letters. Keywords: preparation Zika virus NS2B NS3 inhibitor brain. We’ll tell you more about this compound (cas:67929-86-6).
Zika virus (ZIKV) infection, which initially was endemic only in Africa and Asia, is rapidly spreading throughout Europe, Oceania, and the Americas. Although there have been enormous efforts, there is still no approved drug to treat ZIKV infection. Herein, we report the synthesis and biol. evaluation of agents with noncompetitive mechanism of the ZIKV NS2B/NS3 protease inhibition through the binding to an allosteric site. Compounds 1 and 2 showed potent activity in both enzymic and cellular assays. Derivative 1 efficiently reduced the ZIKV protein synthesis and the RNA replication and prevented the mice from life-threatening infection and the brain damage caused by ZIKV infection in a ZIKV mouse model.
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Reference:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem