Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2-(5-Bromothiophen-2-yl)pyridine, is researched, Molecular C9H6BrNS, CAS is 123784-07-6, about Synthesis of 2-(2-thienyl)pyridine and several of its derivatives.Product Details of 123784-07-6.
Cycloaddition of thiophenecarbonitriles I (R1 = H, Br, R2 = H; R1 = H, R2 = Br) with acetylene gave 25-76% 2-thienylpyridine II; II (R1 = R2 = H) was chlorinated, nitrated, carboxylated, brominated, and acetylated to give thienylpyridines II (R1 = Cl, NO2, CO2H, Br, Ac, R2 = H), resp.
The article 《Synthesis of 2-(2-thienyl)pyridine and several of its derivatives》 also mentions many details about this compound(123784-07-6)Product Details of 123784-07-6, you can pay attention to it, because details determine success or failure
Reference:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem