Computed Properties of C11H11NO3. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Methyl 5-methoxyindole-2-carboxylate, is researched, Molecular C11H11NO3, CAS is 67929-86-6, about Synthesis, spectroscopic identification and molecular docking of certain N-(2-{[2-(1H-indol-2-ylcarbonyl)hydrazinyl](oxo)acetylphenyl)acetamides and N-[2-(2-{[2-(acetylamino)phenyl](oxo)acetylhydrazinyl)-2-oxoethyl]-1H-indole-2-carboxamides: new antimicrobial agents. Author is Almutairi, Maha S.; Zakaria, Azza S.; Al-Wabli, Reem I.; Joe, I. Hubert; Abdelhameed, Ali S.; Attia, Mohamed I..
A series of N-(2-{[2-(1H-indol-2-ylcarbonyl)hydrazinyl](oxo)acetyl}phenyl)acetamides I (R = H, OMe; X = H, F, Cl, Br) and N-[2-(2-{[2-(acetylamino)phenyl](oxo)acetyl}hydrazinyl)-2-oxoethyl]-1H-indole-2-carboxamides I (R = H; X = H, F, Cl, Br) were synthesized. N-acetylisatin derivatives were subjected to ring opening at their C2 carbons with the aid of different indole-bearing hydrazides to afford the resp. glyoxylamides. The antimicrobial activity of the target compounds was assessed with the aid of Diameter of the Inhibition Zone (DIZ) and Min. Inhibitory Concentration (MIC) assays against a panel of Gram-pos. and Gram-neg. bacteria and certain fungal strains. The antimicrobial screening revealed that Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Candida albicans are the most sensitive microorganisms towards the synthesized compounds In addition, compounds I (R = H; X = Cl) and I (R = OMe; X = F) emerged as the most active congeners towards Staphylococcus aureus and Candida albicans, resp. Mol. docking studies revealed the possible binding mode of compounds I (R = H; X = Cl) and I (R = OMe; X = F) to their target proteins.
《Synthesis, spectroscopic identification and molecular docking of certain N-(2-{[2-(1H-indol-2-ylcarbonyl)hydrazinyl](oxo)acetylphenyl)acetamides and N-[2-(2-{[2-(acetylamino)phenyl](oxo)acetylhydrazinyl)-2-oxoethyl]-1H-indole-2-carboxamides: new antimicrobial agents》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(Methyl 5-methoxyindole-2-carboxylate)Computed Properties of C11H11NO3.
Reference:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem