Reference of 2-(5-Bromothiophen-2-yl)pyridine. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2-(5-Bromothiophen-2-yl)pyridine, is researched, Molecular C9H6BrNS, CAS is 123784-07-6, about Synthesis and antibacterial activity of 9-oxime ether non-ketolides, and novel binding mode of alkylides with bacterial rRNA. Author is Liang, Jian-Hua; Lv, Wei; Li, Xiao-Li; An, Kun; Cushman, Mark; Wang, He; Xu, Ying-Chun.
We report a series of new 9-oxime ether non-ketolides, including 3-hydroxyl, 3-O-acyl and 3-O-alkyl clarithromycin derivatives, and thiophene-containing ketolides, e.g. I. Unlike previously reported ketolide 1a, none of them is comparable to telithromycin. A mol. modeling study was performed to gain insight into the binding mode of alkylides with bacterial rRNA and to rationalize the great disparity of their SAR. The results clearly indicated the alkylides with improved antibacterial activity might possess a novel binding mode, which is different from clarithromycin and the alkylides with poor activity.
Different reactions of this compound(2-(5-Bromothiophen-2-yl)pyridine)Reference of 2-(5-Bromothiophen-2-yl)pyridine require different conditions, so the reaction conditions are very important.
Reference:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem