The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《A new weak field tridentate chelating agent. 3,5-Di(2-pyridyl)-1,2,4-triazole》. Authors are Geldard, John F.; Lions, Francis.The article about the compound:3,5-Di(pyridin-2-yl)-4H-1,2,4-triazol-4-aminecas:1671-88-1,SMILESS:NN1C(C2=NC=CC=C2)=NN=C1C3=NC=CC=C3).Application In Synthesis of 3,5-Di(pyridin-2-yl)-4H-1,2,4-triazol-4-amine. Through the article, more information about this compound (cas:1671-88-1) is conveyed.
N2H4.H2O and 2-NCC5H4N gave 3,6-di(2-pyridyl)-1,2-dihydro-1,2,4,5-tetrazine (I), also formed from 2-C5H4NC(:NNH2)NH2. I stirred with aqueous NaNO2 gave 3,6-di(2-pyridyl)-1,2,4,5-tetrazine. I in HCl and made alk. gave 3,5-di(2-pyridyl)-4-amino-1,2,4-trizole (II). II boiled in HNO3, treated with NaNO2, and made alk. gave 3,5-di(2-pyridyl)-1,2,4-triazole, also prepared by heating 2-C5H4NC(:S)NH2 and 2-C5H4NCONHNH2. The residue after NaOH extraction gave 2,5-di(2-pyridyl)-1,3,4-thiadiazole. I treated with aqueous NaNO2 and made alk. gave 2,5-di(2-pyridyl)-1,3,4-oxadiazole (III). II and III are probably produced via a common intermediate. A suggested mechanism was charted schematically.
This compound(3,5-Di(pyridin-2-yl)-4H-1,2,4-triazol-4-amine)Application In Synthesis of 3,5-Di(pyridin-2-yl)-4H-1,2,4-triazol-4-amine was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.
Reference:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem