Ni, Nanting; Laughlin, Sarah; Wang, Yingji; Feng, You; Zheng, Yujun; Wang, Binghe published the artcile< Probing the general time scale question of boronic acid binding with sugars in aqueous solution at physiological pH>, Computed Properties of 721401-43-0, the main research area is boronate sugar carbohydrate.
The boronic acid group is widely used in chemosensor design due to its ability to reversibly bind diol-containing compounds The thermodn. properties of the boronic acid-diol binding process have been investigated extensively. However, there are few studies of the kinetic properties of such binding processes. In this report, stopped-flow method was used for the first time to study the kinetic properties of the binding between three model arylboronic acids, 4-, 5-, and 8-isoquinolinylboronic acids, and various sugars. With all the boronic acid-diol pairs examined, reactions were complete within seconds. The kon values with various sugars follow the order of D-fructose > D-tagatose > D-mannose > D-glucose. This trend tracks the thermodn. binding affinities for these sugars and demonstrates that the ‘on’ rate is the key factor determining the binding constant
Bioorganic & Medicinal Chemistry published new progress about Boronic acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 721401-43-0 belongs to class isoquinoline, and the molecular formula is C9H8BNO2, Computed Properties of 721401-43-0.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem