Burkart, V.; Blaeser, K.; Kolb, H. published their research in Hormone and Metabolic Research on December 31 ,1999. The article was titled 《Potent β-cell protection in vitro by an isoquinolinone-derived PARP inhibitor》.Recommanded Product: 5-Methyl-3,4-dihydroisoquinolin-1(2H)-one The article contains the following contents:
Activation of the nuclear enzyme poly(ADP-ribose)polymerase (PARP) is a critical step in β-cell death in response to exposure with free radicals or other DNA damaging agents. Nicotinamide, a B vitamin, exerts its β-cell protective action primarily via its ability to block excessive PARP activity. We show here that the isoquinolinone derivative PD128763, a specific PARP inhibitor, provides protection from cell death in islet cells exposed in vitro to nitric oxide or oxygen radical generating compounds or to the β-cell toxin streptozotocin, at concentrations 100 times less than required for nicotinamide. Furthermore, while the protective action of nicotinamide is rapidly lost after washing of islet cells, the effects of PD128763 are more long lasting. Both compounds had little capacity to rescue damaged islet cells from subsequent lysis. We conclude that the isoquinolinone derivative PD128763 is superior to nicotinamide in enhancing the resistance of β-cells towards inflammatory attacks. After reading the article, we found that the author used 5-Methyl-3,4-dihydroisoquinolin-1(2H)-one(cas: 129075-56-5Recommanded Product: 5-Methyl-3,4-dihydroisoquinolin-1(2H)-one)
5-Methyl-3,4-dihydroisoquinolin-1(2H)-one(cas: 129075-56-5) belongs to isoquinoline. Isoquinoline is a structural isomer of quinoline, and quinoline derivatives are fused ring compounds of pyridine and benzene rings, which have antiseptic, antipyretic and anti-cyclic properties, and can be used as antimalarial drugs and for the preparation of other antimalarial medicine. Recommanded Product: 5-Methyl-3,4-dihydroisoquinolin-1(2H)-one
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem