Ekhato, I. Victor; Huang, Che C. published an article in Journal of Labelled Compounds and Radiopharmaceuticals. The title of the article was 《Preparation of carbon-14 labeled 3,4-dihydro-5-methyl-1(2H)-isoquinolinone》.Application In Synthesis of 5-Methyl-3,4-dihydroisoquinolin-1(2H)-one The author mentioned the following in the article:
Carbon-14 labeled 3,4-dihydro-5-methyl-1(2H)-isoquinolinone (I) a potent inhibitor of poly(ADP-ribose) polymerase (ADPRP) was prepared from 1-bromo-2-methylbenzene in 7.8% overall yield. The C-14 label was introduced from Ba14CO3 via metal-halogen exchange and carboxylation reactions. In addition to this study using 5-Methyl-3,4-dihydroisoquinolin-1(2H)-one, there are many other studies that have used 5-Methyl-3,4-dihydroisoquinolin-1(2H)-one(cas: 129075-56-5Application In Synthesis of 5-Methyl-3,4-dihydroisoquinolin-1(2H)-one) was used in this study.
5-Methyl-3,4-dihydroisoquinolin-1(2H)-one(cas: 129075-56-5) belongs to isoquinoline. Isoquinoline is a structural isomer of quinoline, and quinoline derivatives are fused ring compounds of pyridine and benzene rings, which have antiseptic, antipyretic and anti-cyclic properties, and can be used as antimalarial drugs and for the preparation of other antimalarial medicine. Application In Synthesis of 5-Methyl-3,4-dihydroisoquinolin-1(2H)-one
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem