Shi, Jianyi; Chen, Zhichao; Lu, Yantong; Xu, Shengting; Wen, Tingting; Luo, Yuehua; Zhu, Zhongzhi; Chen, Xiuwen published the artcile< Nucleophilic Dearomatization Strategy to Synthesize Disubstituted 3-Isoquinolinones under Transition Metal-Free Conditions>, Synthetic Route of 552331-06-3, the main research area is haloisoquinoline alkyl halide indole three component reaction green chem; benzyl indolyl dihydroisoquinolinone preparation.
Herein, a one-pot protocol for constructing the disubstituted isoquinolinone derivatives via the three-component reactions of 3-haloisoquinolines, alkyl halides, and indoles under transition-metal-free conditions was described. The reaction realized the trifunctionalization of isoquinoline via a dearomatization strategy, which displayed high chem. selectivity, excellent functional group tolerance, and a wide range of substrates, and was environmentally friendly. The three-component coupling involves the construction of new C-N, C=O, and C-C bonds in one step.
Journal of Organic Chemistry published new progress about Aralkyl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 552331-06-3 belongs to class isoquinoline, and the molecular formula is C9H5BrClN, Synthetic Route of 552331-06-3.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem