On May 29, 1991, Gueremy, Claude; Malleron, Jean Luc; Mignani, Serge published a patent.Recommanded Product: 4-Bromo-5-nitroisoquinoline The title of the patent was Preparation and formulation of 2-[4-(indolylmethyl)piperidinoethyl]naphthoisothiazole-1,1-dioxides and analogs as serotonin (5HP) reuptake inhibitors. And the patent contained the following:
R1(CH2)nQ [I; Q = Z3R3, Z4R4; R1 = anellated isothiazolo groups Q1-Q3, RSO2N(Z), etc.; R = 2-naphthyl; R3 = 1-indenyl, 1-indanyl, (CH2)mR2, etc.; R2 = indolyl, indanyl, indenyl, quinolyl, etc.; R4 = (CH2)mR2; Y = H, alkyl, alkoxy, Ph; Z = alkyl; Z1 = SO2, CO; Z2 = CH; Z2 may also = N when Z1 = SO2; Z3 = piperidine-1,4-diyl; Z4 = piperazine-1,4-diyl, 1,2,3,6-tetrahydropyridine-1,4-diyl; m = 1, 2; n = 2, 3] were prepared Thus, BrCH2CH2Cl was condensed with 1,8-naphthosultam and the product condensed with 4-[(5-fluoro-3-indolyl)methyl]piperidine to give, after N-methylation, title compound II. I had IC50 < 25 nM for binding of paroxetine (substrate not given). The experimental process involved the reaction of 4-Bromo-5-nitroisoquinoline(cas: 58142-46-4).Recommanded Product: 4-Bromo-5-nitroisoquinoline
The Article related to naphthoisothiazole indolylmethylpiperidinoethyl serotonin reuptake inhibitor, indolylmethylpiperidinoethylnaphthoisothiazole preparation serotonin reuptake inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Recommanded Product: 4-Bromo-5-nitroisoquinoline
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem