On October 22, 2020, Marx, Matthew Arnold; Christensen, James Gail; Smith, Christopher Ronald; Fischer, John P.; Burns, Aaron Craig published a patent.Recommanded Product: 4-Bromo-5-nitroisoquinoline The title of the patent was Preparation of pyridopyrimidine derivatives as KRas G12C inhibitors for the treatment of KRas-mediated diseases. And the patent contained the following:
The invention relates to preparation of pyridopyrimidines, e.g., I, that inhibit KRas G12C. Thus, I was prepared via intermediate II. Pyridopyrimidines of the invention are irreversible inhibitors of KRas G12C (data given) and can be used in treatment of diseases that are KRas-mediated as well as caused by KRas G12C mutation. The experimental process involved the reaction of 4-Bromo-5-nitroisoquinoline(cas: 58142-46-4).Recommanded Product: 4-Bromo-5-nitroisoquinoline
The Article related to pyridopyrimidine preparation kras g12c inhibitor disease treatment, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Recommanded Product: 4-Bromo-5-nitroisoquinoline
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem