On August 8, 2001, Peglion, Jean-louis; Dessinges, Aimee; Poitevin, Christophe; Vilaine, Jean-paul; Villeneuve, Nicole; Thollon, Catherine; Bourguignon, Marie-pierre published a patent.Formula: C9H5BrN2O2 The title of the patent was Preparation of N-piperidinyl(alkyl)isoquinolinesulfonamides and analogs for treatment of vascular disease. And the patent contained the following:
RSO2NR1Z1ZZ2R2 [I; R = (un)substituted (hetero)aryl; R1 = H or alkyl; R2 = (un)substituted 2- or 3-indenyl or -benzofuranyl; Z = (4-hydroxy)piperidine-4,1-diyl; Z1 = bond or alkylene; Z2 = (un)substituted alk(en)ylene] were prepared Thus, Et 4-piperidinecarboxylate was converted in 5 steps to title compound II. Data for biol. activity of 1 prepared I were given. The experimental process involved the reaction of 4-Bromo-5-nitroisoquinoline(cas: 58142-46-4).Formula: C9H5BrN2O2
The Article related to piperidinylalkylisoquinolinesulfonamide preparation vascular disease treatment, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.Formula: C9H5BrN2O2
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem