On January 6, 1976, Serban, Alexander published a patent.Category: isoquinoline The title of the patent was 3-Chloro-5-acetamidoisoquinoline as a herbicide. And the patent contained the following:
Isoquinolines I (R = H, halo, NO2, NH2, AcNH, CN; R1 = H, Me, Bu, NO2, NH2, halo, CN, Me) and I.HR2 [R2 = Cl, CF3CO2, Br, iodide, C6Cl5O, 2,4-(O2N)2C6H3O, substituted phenoxy, ClCF2CO2, 2,4-(O2N)2C6H3CO2] (∼110 compounds), which possessed herbicidal, insecticidal, acaricidal, and fungicidal activity, were prepared Isoquinolines were nitrated by H2SO4-KNO3 to give nitro derivatives of I which were reduced to the amino derivatives; Sandmeyer or Schiemann reaction of aminoisoquinolines yielded halo derivatives of I. The title compound was a selective herbicide at 0.25-10 lb/acre against ipomoea, mustard, and sunflower in areas cultivated in wheat, peas, yegrass, or oats. I.HR2 (R = H, 5-Cl, 5-Br, 5-NO2; R1 = H, 1-Me; R2 = Cl, substituted phenoxy) controlled cabbage moth at 0.2% weight/vol and I.HR2 (R = H, 5-NO2; R1 = H, 3-Me; R2 = iodide, CF3CO2) at 1% weight/volume possessed ∼100% effective acaricidal activity against cattle tick nymphs and engorged adults. 4-Bromo-5-nitroisoquinoline possessed fungicidal activity against wheat powdery mildew at 0.008% weight/volume The experimental process involved the reaction of 4-Bromo-5-nitroisoquinoline(cas: 58142-46-4).Category: isoquinoline
The Article related to isoquinoline nitro insecticide, haloisoquinoline herbicide, nitroalkylisoquinoline acaricide, bromonitroisoquinoline fungicide, chloroacetamidoisoquinoline herbicide, acetamidochloroisoquinoline herbicide and other aspects.Category: isoquinoline
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem