On June 7, 2022, Tang, Feng; Li, Zhen; Zhang, Guobao; Zhou, Feng; Chen, Ping; Ren, Jinsheng published a patent.Product Details of 58142-46-4 The title of the patent was Preparation of (piperazinyl)tetrahydropyridopyrimidine derivatives and application for treating KRAS G12C mutant tumors. And the patent contained the following:
The present invention relates to the preparation of (piperazinyl)tetrahydropyridopyrimidine derivatives and uses thereof. In particular, (piperazinyl)tetrahydropyridopyrimidine derivatives I (R is -C(R6)=CH(R7), furanyl, -CH(F)(Cl), etc.; Q is selected from C=O or S(=O)2; R1 is selected from heterocyclyl or NR4R5; R2 is selected from aryl or heteroaryl; R3 is selected from hydrogen or NC-CH2; R4 and R5 are independently selected from hydrogen, alkyl, aryl or heteroaryl, alkylacyl, C1-4 alkyloxyacyl, or R4 and R5 together with the nitrogen atom to which they are attached form a heterocyclyl; R6 is selected from hydrogen or fluorine; R7 is selected from hydrogen, halogen, C1-4 alkyl or C1-4 alkoxy, described C1-4 alkyl or C1-4 alkoxy is optionally by =O, halogen, C1-4 alkoxy, etc.; n is selected from 0, 1, 2; m is selected from 1, 2, 3) were prepared The inventive compounds or a pharmaceutically acceptable salts, pharmaceutical compositions are used in preparation of medicaments for preventing and/or treating KRAS G12C mutant tumors. The experimental process involved the reaction of 4-Bromo-5-nitroisoquinoline(cas: 58142-46-4).Product Details of 58142-46-4
The Article related to piperazinyl tetrahydropyridopyrimidine preparation antitumor agent, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Product Details of 58142-46-4
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem