Cormick, Justin published the artcileThe synthesis of MDA from helional and characterisation by isotope ratio mass spectrometry, Application of 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, the main research area is synthesis MDA isotope ratio mass spectrometry.
Presented here is an investigation into the stable isotopic ratios of 3,4-methylenedioxyamphetamine (MDA) prepared from the alternative precursor helional. Two methods for the synthesis of MDA were investigated, both utilizing hydroxylamine as the nitrogen source. Recent publications found both helional and hydroxylamine with isotopic compositions significantly different to traditional precursors and nitrogen sources. While minimal fractionation was observed in carbon isotopic compositions, apparent fractionation occurred to hydrogen, nitrogen and oxygen isotopic compositions during the synthesis of MDA. Fractionation observed in δ15N were explained by the reaction conditions during the addition of hydroxylamine. The fractionation observed in δ18O was consistent with the replacement and loss of an oxygen atom during the synthesis of the amide intermediate and MDA. A brief investigation into isotopic fractionation during MDA hydrogen chloride (HCl) salt precipitation was also conducted, and addnl. fractionation may be expected in both δ2H and δ15N during the process, consistent with the proposed mechanism. These results suggest that tactical intelligence can be gained from the batch-to-batch variations to isotopic composition of MDA during the synthesis from helional.
Forensic Chemistry published new progress about Isotope effect. 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Application of 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem