El-Athman, Fatima published the artcileReaction kinetics of corrinoid-mediated deiodination of iodinated X-ray contrast media and other iodinated organic compounds, Formula: C11H9I3N2O4, the main research area is iodinated contrast media organic compound reaction kinetics corrinoid deiodination; Abiotic; Dehalogenation; Electron shuttle; Halogenated organic compound; Vitamin B(12).
Iodinated contrast media are found at considerably higher concentrations than any other pharmaceutical in waste water, surface water and bank filtrate. While the compounds are persistent to deiodination in aerobic environments, field data from bank filtration transects have demonstrated a partial deiodination in reducing soil-water environments. In a previous lab study, we have shown that this reductive deiodination is abiotically catalyzed by (free) corrinoids. We now investigated the reaction kinetics based on the decrease of the iodinated compound, the formation of deiodinated transformation products and the iodide release. The deiodination rate decreased with decreasing iodination degree with the deiodination rate constants k1 > k2 > k3. In contrast to the ICM, 2,4,6- and 2,3,5-triiodobenzoic acid, 5-amino-2,4,6-triiodoisophthalic acid and monoiodobenzoic acids did not show a complete deiodination under the same test conditions. Our results show that the deiodination strongly depends on the substitution pattern of the bound iodine atoms as well as on adjacent functional groups. Iodine atoms in ortho-position to another iodine atom or a carboxyl group were released more easily while an amino group in ortho-position inhibited the deiodination. Tests in tap water in the presence of B12 showed a much slower deiodination than in ultrapure water, most likely caused by competitive electron acceptors in the water matrix.
Chemosphere published new progress about Carboxyl group. 117-96-4 belongs to class isoquinoline, name is Diatrizoic Acid, and the molecular formula is C11H9I3N2O4, Formula: C11H9I3N2O4.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem