Jin, Lei published the artcileSimultaneous optimization of the extraction process of Yangyin Yiqi Huoxue prescription with natural deep eutectic solvents for optimal extraction yield and antioxidant activity: A comparative study of two models, Computed Properties of 598-50-5, the main research area is Yangyin Yiqi Huoxue prescription extraction optimization deep eutectic solvent; Genetic neural network; Natural deep eutectic solvents; Response surface methodology; Yangyin Yiqi Huoxue prescription; bi-objective optimization.
Natural deep eutectic solvents (NaDESs) are green and effective solvents that are used to extract 3 flavonoids from Yangyin Yiqi Huoxue prescription, a traditional Chinese prescription. A total of 6 types of NaDESs were systematically screened and evaluated for the total extraction yield of puerarin, calycosin, and formononetin by high-performance liquid chromatog. Then, a 4-factor-three-level exptl. scheme designed by the Box-Benhnken Design was applied on the basis of a single experiment to determine the extraction yield and the antioxidant property. Finally, the extraction process was optimized through response surface methodol. (RSM) and the genetic neural network (GNN), resp. The use of betaine-lactic acid as an extractant displayed significant advantages in the screening process. The optimum extraction parameters provided by GNN were as follows: water content 25% (volume/volume), liquid to material ratio 190 mg/mL, extraction time 37 min, and extraction temperature 63°C. Under this condition, the average exptl. comprehensive evaluation values of the extraction yield and antioxidant properties were 3.12 mg/g and 86.27%, and the relative deviations to the predicted values were 0.30% and 1.44%, resp. In addition, the exptl. results of GNN were better than those of RSM (p < 0.01). We found the application of GNN to be effective and credible for bi-objective optimization of extraction yields and antioxidant activity in this study. Moreover, our results provide a reference and a theor. basis for exptl. and future industrial extraction for multi-objective situations. Phytomedicine published new progress about Antioxidants. 598-50-5 belongs to class isoquinoline, name is 1-Methylurea, and the molecular formula is C2H6N2O, Computed Properties of 598-50-5.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem