Magotra, Asmita published the artcilePharmacokinetic evaluation of medicinally important synthetic N,N’ diindolylmethane glucoside: Improved synthesis and metabolic stability, Safety of 2,3-Dimethoxybenzaldehyde, the main research area is disaccharide glycoside pharmacokinetic diindolylmethane glucoside metabolic stability human; Fe/Al pillared catalyst; Hepatic extraction ratio; Metabolic stability; N-Glycoside; Pharmacokinetics.
An improved route for the synthesis of N,N’-diindolyl methane (DIM) glycosides has been developed by using Fe/Al pillared clay catalyst. In-silico pharmacokinetics followed by in-vitro studies like aqueous solubility, lipophilicity, P-glycoprotein (P-gp) dependent ATPase activity, permeability, plasma protein binding, RBC partitioning, metabolic stability in different liver microsomes and its in-vitro-in-vivo extrapolation were conducted for the most potent derivative namely NGD16. The compound was found to have low solubility, optimum lipophilicity, no P-gp inhibitory activity, intermediate permeability, high plasma protein binding, low RBC partitioning, acceptable metabolic stability in rat liver microsomes (RLM) as well as human liver microsomes (HLM) with intermediate hepatic extraction ratio.
Bioorganic & Medicinal Chemistry Letters published new progress about Homo sapiens. 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Safety of 2,3-Dimethoxybenzaldehyde.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem