Musa, Musiliyu A. published the artcileIdentification of 7,8-dihydroxy-3-phenylcoumarin as a reversible monoamine oxidase enzyme inhibitor, Application of 4-Methoxyphenylacetic acid, the main research area is dihydroxy phenylcoumarin monoamine oxidase enzyme inhibitor neuroprotection; 3-arylcoumarin; molecular modeling; monoamine oxidase inhibitors; neuroprotection; structure-activity relationship.
We herein report the biol. evaluation of 3-arylcoumarin derivatives (3a-l) as potential human monoamine oxidase-A and -B (hMAO-A and hMAO-B) inhibitors. The result indicated that 7,8-dihydroxy-3-(4-nitrophenyl)coumarin (3j) was most effective against MAO-A (inhibition concentration [IC50] = 6.46 ± 0.02μM) and MAO-B (IC50 = 3.8 ± 0.3μM) enzymes than other synthesized compounds and reference compounds (pargyline and moclobemide). Furthermore, compound (3j) showed (a) nonselectivity against hMAO enzymes, (b) reversible hMAO enzymes inhibition, and (c) neuroprotection against H2O2-treated human neuroblastoma (N2a) cells. Finally, a mol. modeling study revealed that the hMAO enzymes inhibitory activity of the compound (3j) may be due to the orientation where the nitro (NO2) group lies deep into the receptor and the Ph ring directed toward flavin adenosine dinucleotide via hydrogen bond interaction, and possible π-π interaction with various important residues. Thus, the results of the present study demonstrate that compound (3j) can be considered as a promising scaffold for the development of hMAO-A and hMAO-B inhibitors.
Journal of Biochemical and Molecular Toxicology published new progress about Homo sapiens. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Application of 4-Methoxyphenylacetic acid.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem