Wang, Cong published the artcileDiscovery of chalcone-modified estradiol analogs as antitumour agents that Inhibit tumour angiogenesis and epithelial to mesenchymal transition, Name: 2,3-Dimethoxybenzaldehyde, the main research area is estradiol chalcone analog preparation antitumor antiangiogenic; 2-Methoxyestradiol; Angiogenesis; Antitumour; EMT; Migration.
Angiogenesis plays an essential role in tumorigenesis and tumor progression, and anti-angiogenesis therapies have shown promising antitumor effects in solid tumors. 2-Methoxyestradiol (2ME2), an endogenous metabolite of estradiol, has been regarded as a potential antitumor agent mainly targeting angiogenesis. Here we synthesized a novel series of chalcones based on 2-methoxyestradiol and evaluated their potential activities against tumors. Compound I was demonstrated to have potent antiangiogenic activity. Further studies showed that I suppressed tumor growth in human breast cancer (MCF-7) xenograft models without obvious side effects. Evaluation of the mechanism revealed that I targeted the epithelial to mesenchymal transition (EMT) process in MCF-7 cells and inhibited HUVEC migration and then contributed to hindrance of angiogenesis. Thus, I may be a promising antitumor agent with excellent efficacy and low toxicity.
European Journal of Medicinal Chemistry published new progress about Angiogenesis. 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Name: 2,3-Dimethoxybenzaldehyde.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem