Waters, Nigel J. published the artcileUse of the Oie-Tozer model in understanding mechanisms and determinants of drug distribution, Application In Synthesis of 117-96-4, the main research area is aminohexanoic acid biapenem carboplatin imipenem pharmacokinetics.
Volume of distribution (VD) is a key pharmacokinetic property that together with clearance determines the half-life or residence time of drug in the body. It is commonly expressed as steady-state volume of distribution VDss with a physiol. basis for its understanding developed by Oie and Tozer in 1979. The Oie-Tozer equation uses terms for plasma protein binding (fup), tissue binding (fut), and the extravascular/intravascular ratio of albumin as well as constants for the volumes of plasma, extracellular fluid, and tissue. We explored this model using a data set of 553 drugs for which VDss and plasma protein binding were available in humans. Eighteen percent of cases (102 compounds) did not obey the Oie-Tozer model, with the rearranged equation giving an aberrant fut value (fut < 0 or fut > 1), in particular for compounds with VDss < 0.6 l/kg and fup > 0.1. Further anal. of this group of compounds revealed patterns in physicochem. attributes with a high proportion exemplified by logP less than 0 (i.e., very hydrophilic), polar surface area > 150 Å2, and a difference between logP and logD > 2.5. In addition there was a high representation of certain drug classes including anti-infectives as well as neuromuscular blockers and contrast agents. The majority of compounds were also found to have literature evidence, implicating active transport processes in their disposition. This anal. provides some important insights for pharmacokinetic optimization in this particular chem. space, as well as in the application of the Oie-Tozer model for predicting volume of distribution in humans.
Drug Metabolism and Disposition published new progress about Homo sapiens. 117-96-4 belongs to class isoquinoline, name is Diatrizoic Acid, and the molecular formula is C11H9I3N2O4, Application In Synthesis of 117-96-4.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem