Boleda, M. Rosa published the artcileValidation and uncertainty estimation of a multiresidue method for pharmaceuticals in surface and treated waters by liquid chromatography-tandem mass spectrometry, SDS of cas: 117-96-4, the main research area is validation uncertainty estimation multiresidue pharmaceutical water; liquid chromatog tandem mass spectrometry.
The estimation of measurement uncertainty associated with quant. results is essential to assure the reliability of anal. methods and mandatory when a laboratory implements ISO standard 17025. A quant. multi-residue method based on solid-phase extraction (SPE) and ultra-performance liquid chromatog. tandem mass spectrometry detection (LC-MS/MS) was developed and validated for the anal. of 53 pharmaceuticals (analgesics, anti-inflammatories, antibiotics, lipid regulating agents, cholesterol lowering stating agents, gastric drugs, x-ray, and miscellaneous compounds such as sildenafil, prednisone, triclosan, chlorhexidine and miconazole) in surface and drinking waters. A full validation of the method, according to ISO standard 17025 procedure, was performed. Linearity (0.01-250 ng/L), intra-day precision (3-19% RSD in surface water and 2-19% RSD in drinking water) and inter-day precision (3-16% RSD in surface water and 1-18% RSD in drinking water), matrix effects (low matrix effects were observed for 50% of compounds in both matrixes), limits of quantification (0.2-40 ng/L in surface water and 0.2-30 ng/L in drinking water) were calculated The recoveries at 100 ng/L were >80% for 72 and 79% of the target compounds in surface and drinking waters, resp. The information obtained from the full method validation was used to estimate the expanded uncertainty and the uncertainties contributions of the different individual steps of the method for the determination of pharmaceuticals at trace levels in waters. Expanded relative uncertainties were 6-23% being the uncertainty associated with reproducibility the main contribution.
Journal of Chromatography A published new progress about Analgesics. 117-96-4 belongs to class isoquinoline, name is Diatrizoic Acid, and the molecular formula is C11H9I3N2O4, SDS of cas: 117-96-4.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem