Lim, Chang-Keun published the artcileIodinated Photosensitizing Chitosan: Self-Assembly into Tumor-Homing Nanoparticles with Enhanced Singlet Oxygen Generation, HPLC of Formula: 117-96-4, the main research area is iodination photosensitizer chitosan self assembly antitumor nanoparticle singlet oxygen.
A novel iodinated chitosan-backboned conjugate (GC-I-Ce6) was designed and prepared to fabricate self-assembled biopolymeric nanoparticles with heavy atom-effected enhanced singlet oxygen generation as well as biol. merits. The heavy atom-rich nature of the hydrophobic particle interior was characterized with X-ray absorption and the modified photophys. properties of a chem. embedded photosensitizer, chlorin e6 (Ce6). From the comparative spectroscopic studies as well as cellular and animal experiments, it has been shown that the self-assembled GC-I-Ce6 nanoparticles have enhanced capability of singlet oxygen generation by the intraparticle heavy-atom effect, along with high tumor targetability in vitro and in vivo thanks to the glycol chitosan-surfaced exterior with biocompatible, pos. charged and tumor-homing characteristics. Actual efficacy improvement in the photodynamic therapy of a human breast cancer cell line (MDA-MB-231) demonstrates potential of our photophys. and pharmaceutically motivated hybrid bioconjugate approach for nanomedicine applications.
Bioconjugate Chemistry published new progress about Amphiphiles. 117-96-4 belongs to class isoquinoline, name is Diatrizoic Acid, and the molecular formula is C11H9I3N2O4, HPLC of Formula: 117-96-4.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem