Lori, G. published the artcileHoney extracts inhibit PTP1B, upregulate insulin receptor expression, and enhance glucose uptake in human HepG2 cells, Synthetic Route of 104-01-8, the main research area is heaptocellular carcinoma glycemic honey PTP1B insulin receptor glucose; Insulin signaling; Phenolic compounds; Protein-tyrosine phosphatase 1B; Tuscany honey; Type 2 diabetes.
Honey is a food known for its medical properties. In this work, we have studied the impact of different types of honey on insulin signalling pathway. We found that honey extracts inhibit the enzyme PTP1B, one of the main neg. regulators of insulin receptor signalling. HPLC-MS anal. allowed us to confirm the presence of several natural PTP1B inhibitors in the honey extracts analyzed. Statistical anal. methods show a correlation between specific 1H-NMR resonance frequencies/HPLC peaks and the inhibitory power of the samples. This finding will allow the prediction of the biol. properties of honey samples applying relative simple anal. methods. Finally, we demonstrated that the treatment of HepG2 cells with honey extracts enhances the expression of insulin receptor, and stimulates glucose uptake. For the first time, our results demonstrate that bioactive components of honey could improve glycemic control by both inhibiting PTP1B and stimulating the expression of insulin receptor in liver cells.
Biomedicine & Pharmacotherapy published new progress about Acacia. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Synthetic Route of 104-01-8.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem