Natsch, Andreas published the artcileDeriving a no expected sensitization induction level for fragrance ingredients without animal testing: an integrated approach applied to specific case studies, Recommanded Product: 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, the main research area is fragrance ingredient sensitization complimentary alternative testing risk assessment.
Cosmetic regulations prohibit animal testing for the purpose of safety assessment and recent registration, evaluation and authorization of chems. guidance states that the local lymph node assay (LLNA) in mice shall only be conducted if in vitro data cannot give sufficient information for classification and labeling. However, Quant. Risk Assessment for fragrance ingredients requires an NESIL (no expected sensitization induction level), a dose not expected to cause induction of skin sensitization in humans. In absence of human data, this is derived from the LLNA and it remains a key challenge for risk assessors to derive this value from nonanimal data. Here we present a workflow using structural information, reactivity data and KeratinoSens results to predict an LLNA result as a point of departure. Specific addnl. tests (metabolic activation, complementary reactivity tests) are applied in selected cases depending on the chem. domain of a mol. Finally, in vitro and in vivo data on close analogs are used to estimate uncertainty of the prediction in the specific chem. domain. This approach was applied to three mols. which were subsequently tested in the LLNA and 22 mols. with available and sometimes discordant human and LLNA data. Four addnl. case studies illustrate how this approach is being applied to recently developed mols. in the absence of animal data. Estimation of uncertainty and how this can be applied to determine a final NESIL for risk assessment is discussed. We conclude that, in the data-rich domain of fragrance ingredients, sensitization risk assessment without animal testing is possible in most cases by this integrated approach.
Toxicological Sciences published new progress about Allergy. 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Recommanded Product: 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem