Ye, Zenghui published the artcilePIDA-Mediated Rearrangement for the Synthesis of Enantiopure Triazolopyridinones, Application In Synthesis of 104-01-8, the main research area is hydrazide diacetoxyiodobenzene tandem oxidative cyclization carbon migration rearrangement; triazolopyridinone preparation.
A tandem oxidative cyclization/1,2-carbon migration of hydrazides for the synthesis of otherwise inaccessible hindered or enantiopure triazolopyridinones has been developed. This protocol exhibits broad substrate scope and can be easily scaled up by continuous flow synthesis under mild conditions. Most importantly, this method demonstrates a rearrangement with retention of configuration and can be readily applied for the late-stage modification of carboxylic-acid-containing pharmaceuticals, amino acids, and natural products to access enantiopure triazolopyridinones.
Organic Letters published new progress about Flow. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Application In Synthesis of 104-01-8.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem