Plewe, Michael B. published the artcileSAR studies of 4-acyl-1,6-dialkylpiperazin-2-one arenavirus cell entry inhibitors, Quality Control of 104-01-8, the main research area is acyl dialkyl piperazinone preparation structure arenavirus cell entry inhibitor; Arenavirus; Entry inhibitor; Junin; Lassa; Machupo; Piperazinone.
Old World (Africa) and New World (South America) arenaviruses are associated with human hemorrhagic fevers. Efforts to develop small mol. therapeutics have yielded several chem. series including the 4-acyl-1,6-dialkylpiperazin-2-ones. Herein, we describe an extensive exploration of this chemotype. In initial Phase I studies, R1 and R4 scanning libraries were assayed to identify potent substituents against Old World (Lassa) virus. In subsequent Phase II studies, R6 substituents and iterative R1, R4 and R6 substituent combinations were evaluated to obtain compounds with improved Lassa and New World (Machupo, Junin, and Tacaribe) arenavirus inhibitory activity, in vitro human liver microsome metabolic stability and aqueous solubility
Bioorganic & Medicinal Chemistry Letters published new progress about Antiviral agents. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Quality Control of 104-01-8.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem