Yang, Heng published the artcileDBU-Promoted Intramolecular Crossed Aldol Reaction: A Facile Access to Indane-Fused Pyrrolidine, Application In Synthesis of 86-51-1, the main research area is DBU catalyst intramol cross aldol addition; indane fused pyrrolidine preparation.
A new strategy for the facile synthesis of indane-fused pyrrolidines through DBU-promoted intramol. crossed aldol reaction has been developed. The efficiency, compatibility and practicality of this method were demonstrated by a broad substrate scope, mild reaction conditions and gram-scale synthesis. The further derivatizations of the synthesized diastereoisomers I and II were performed for arylation, alkenylation, amination and etherification, showing high diastereoselectivities. Deuterium labeling experiment suggests a possible carbocation process which leads to the high diastereoselectivity during the transformations of I and II. Based on this strategy, the 5-HT2C agonist III and the antihypertensive agent IV were successfully synthesized through a three-step synthetic pathway. This new strategy potentially enables a wide exploration of these indane-fused derivatives applied for pharmaceuticals and related fields.
European Journal of Organic Chemistry published new progress about Aldol addition. 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Application In Synthesis of 86-51-1.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem