Effect of pH of the medium on chemical shifts in PMR spectra and the distribution of π-electron density. II. 4-Hydroxyisoquinoline derivatives was written by Lezina, V. P.;Andronova, N. A.;Smirnov, L. D.;Dyumaev, K. M.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1971.Category: isoquinoline This article mentions the following:
The chem. shift of the C-1 and C-3 protons in 4-hydroxy- and 4-methoxyisoquinoline, 2-methyl-4-hydroxy-isoquinolinium iodide, and 3-piperidinomethyl- and 3-methyl-4-hydroxyisoquinoline decreased with increasing pH; the π-electron d. of C-1 and C-3 was higher in acid than in basic media. In the experiment, the researchers used many compounds, for example, 4-Methoxyisoquinoline (cas: 36034-54-5Category: isoquinoline).
4-Methoxyisoquinoline (cas: 36034-54-5) belongs to isoquinoline derivatives. Being an analog of pyridine, isoquinoline is a weak base, with a pKa of 5.14. It protonates to form salts upon treatment with strong acids, such as HCl. It forms adducts with Lewis acids, such as BF3.Category: isoquinoline
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem