Dipole moment and infrared studies of solvent effects on intramolecular hydrogen bonding. IV. Nitroanilines and nitronaphthylamines was written by Richards, J. H.;Walker, W.. And the article was included in Transactions of the Faraday Society in 1961.Application In Synthesis of Isoquinolin-7-amine This article mentions the following:
The molar refraction and the dipole moment, resp., were determined for o-C6H4(NO2)2 in C6H6 as 38.09 and 4.06; in dioxane 42.84 and 4.36; 2,6(NO2)2C6H3NH2 in C6H6 as 48.06 and 1.93, in dioxane 50.83 and 1.69; 2-nitro-1-naphthylamine in dioxane 54.36 and 4.92; 1-nitro-2-naphthylamine in C6H6 as 58.85 and 4.45, in dioxane 61.07 and 4.74; 3-nitro-2-naphthylamine in C6H6 as 54.65 and 3.82, in dioxane 54.89 and 4.09; 8-nitro-1-naphthylamine in dioxane 54.03 and 3.11; 6-amino-5,7-dinitro-1,2,3,4-tetrahydronaphthalene in C6H6 as 64.72 and 3.29, in dioxane 64.72 and 3.02. The infrared spectra of BuNH2 (b. 77.5°), 3-nitro-2-naphthylamine, and 2,6-dinitroaniline were determined in CCl4 and dioxane. The Bellamy-Williams equation (relating the NH2 group sym. and antisym. stretching frequencies one to the other) was valid for ortho-substituted aniline compounds where unilateral intramol. H bonding can be excluded. In the experiment, the researchers used many compounds, for example, Isoquinolin-7-amine (cas: 23707-37-1Application In Synthesis of Isoquinolin-7-amine).
Isoquinolin-7-amine (cas: 23707-37-1) belongs to isoquinoline derivatives. Isoquinoline is a structural isomer of quinoline, which have antiseptic, antipyretic and anti-cyclic properties, and can be used as antimalarial drugs and for the preparation of other antimalarial medicine. Most traditional methods of generating isoquinoline do so via oxidative aromatization of dihydro- or tetrahydro-isoquinolines, usually offering some environmental or economic advantage.Application In Synthesis of Isoquinolin-7-amine
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem