Design and synthesis of unique thiazoloisoquinolinium thiolates and derivatives was written by Ahmed, Wasim;Huang, Zi-Hao;Cui, Zi-Ning;Tang, Ri-Yuan. And the article was included in Chinese Chemical Letters in 2021.COA of Formula: C10H9NO This article mentions the following:
The synthesis of unique mesoionic thiazoloisoquinolinium thiolates stabilized by aromatization and 1,3-dipolarization. Herein, compounds were synthesized via the three component [2+2+1] cycloaddition reaction of isoquinolines with Et propionate and elemental sulfur in the absence of any metal catalyst and additives. Importantly, thiazoloisoquinolinium thiolates were transformed to thioether-containing thiazoloisoquinolinium halides. A selective [4+2] cycloaddition were also used to form S-bridged fused tetracyclic compounds with a thiothiamide ring unit and two quaternary carbon centers. Compound I showed good bioactivity against the chlorophyll of duckweed (Lemna minor) with inhibition rate of 51.5μg/mL. In the experiment, the researchers used many compounds, for example, 4-Methoxyisoquinoline (cas: 36034-54-5COA of Formula: C10H9NO).
4-Methoxyisoquinoline (cas: 36034-54-5) belongs to isoquinoline derivatives. Being an analog of pyridine, isoquinoline is a weak base, with a pKa of 5.14. It protonates to form salts upon treatment with strong acids, such as HCl. It forms adducts with Lewis acids, such as BF3.COA of Formula: C10H9NO
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem