6,7-Dihydroisoquinolin-8(5H)-one hydrochloride (cas: 135311-97-6) belongs to isoquinoline derivatives. Isoquinoline is a structural isomer of quinoline, which have antiseptic, antipyretic and anti-cyclic properties, and can be used as antimalarial drugs and for the preparation of other antimalarial medicine. Most traditional methods of generating isoquinoline do so via oxidative aromatization of dihydro- or tetrahydro-isoquinolines, usually offering some environmental or economic advantage.Related Products of 135311-97-6
Synthesis, optical resolution, absolute configuration, and preliminary pharmacology of (+)- and (-)-cis-2,3,3a,4,5,9b-hexahydro-1-methyl-1H-pyrrolo[3,2-h]isoquinoline, a structural analog of nicotine was written by Glassco, William;Suchocki, John;George, Clifford;Martin, Billy R.;May, Everette L.. And the article was included in Journal of Medicinal Chemistry in 1993.Related Products of 135311-97-6 This article mentions the following:
Title compound, I, was prepared from isoquinoline, and separated into its antipodes with D– and L-di-p-toluoyltartaric acids. These bridged nicotine analogs either are binding to an as-yet-unidentified nicotinic receptor or they represent a novel class of nonnicotinic analgesics. However, (+)-I failed to compete for [3H]-nicotine binding, and its pharmacol. effects were not blocked by mecamylamine. Isomer (+)-I has the 3aR,9bS configuration, the latter corresponding to (S)-(-)-nicotine as determined by x-ray crystallog. Compound (-)-I was one fourth as potent. The most potent compound, (+)-I, had an ED50 of 7.13 μmol/kg for inhibition of spontaneous activity and 7.45 μmol/kg for antinociception compared to 4.44 and 4.81 μmol/kg, resp., for (S)-(-)-nicotine. These antipodes and the racemic precursor were evaluated in in vivo systems for their effects. These bridged nicotine analogs either are binding to an as-yet-unidentified nicotinic receptor or they represent a novel class of nonnicotinic analgesics. In the experiment, the researchers used many compounds, for example, 6,7-Dihydroisoquinolin-8(5H)-one hydrochloride (cas: 135311-97-6Related Products of 135311-97-6).
6,7-Dihydroisoquinolin-8(5H)-one hydrochloride (cas: 135311-97-6) belongs to isoquinoline derivatives. Isoquinoline is a structural isomer of quinoline, which have antiseptic, antipyretic and anti-cyclic properties, and can be used as antimalarial drugs and for the preparation of other antimalarial medicine. Most traditional methods of generating isoquinoline do so via oxidative aromatization of dihydro- or tetrahydro-isoquinolines, usually offering some environmental or economic advantage.Related Products of 135311-97-6
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem