5-Bromoisoquinolin-8-amine (cas: 90721-35-0) belongs to isoquinoline derivatives. Quinoline is a mancude organic heterobicyclic parent, an azaarene, an ortho-fused heteroarene and a member of isoquinolines. Lewis acid activation and nucleophilic attack can produce multiple regioisomers in quinolines and pyridines; isoquinolines generally only undergo attack at the 1-position.Electric Literature of C9H7BrN2
New N-aryl-N’-(3-(substituted)phenyl)-N’-methylguanidines as leads to potential PET radioligands for imaging the open NMDA receptor was written by Naumiec, Gregory R.;Cai, Lisheng;Pike, Victor W.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2015.Electric Literature of C9H7BrN2 This article mentions the following:
An expansive set of N-aryl-N’-(3-(substituted)phenyl)-N’-(methyl)guanidine was prepared in a search for new leads to prospective PET ligands for imaging of the open channel of the N-methyl-D-aspartate (NMDA) receptor in vivo. The N-aryl rings and their substituents were varied, whereas the N-methyl-group was maintained as a site for potential labeling with the positron-emitter, carbon-11 (t1/2 = 20.4 min). At micromolar concentration, over half of the prepared compounds strongly inhibited the binding of [3H]TCP to its binding site in the open NMDA receptor in vitro. Four ligands displayed affinities that are similar or superior to those of the promising SPECT radioligand ([123I]CNS1261). The 3′-dimethylamine-derivative (Ki 36.7 nM), 3′-trifluoromethyl-derivative (Ki 18.3 nM) and 3′-methylthio-derivative (Ki 39.8 nM) of N-(1-naphthyl)-N’-(phenyl)-N’-(methyl)guanidine were identified as especially attractive leads for PET radioligand development. The synthesis of the target compounds was achieved using amines as reactants, such as 3-bromo-4-fluoro-N-(methyl)benzenamine, 1-naphthalenamine, 2-naphthalenamine, 1-isoquinolinamine, 5-isoquinolinamine, 8-quinolinamine and related substances [N-(methyl)arenamine] derivatives The title compounds thus formed included N-methyl-N-[3-(methylthio)phenyl]-N‘-(1-naphthalenyl)guanidine, N-methyl-N‘-(1-naphthalenyl)-N-[3-(trifluoromethyl)phenyl]guanidine, N-(4-fluoro-3-methylphenyl)-N-methyl-N‘-(-naphthalenyl)guanidine. In the experiment, the researchers used many compounds, for example, 5-Bromoisoquinolin-8-amine (cas: 90721-35-0Electric Literature of C9H7BrN2).
5-Bromoisoquinolin-8-amine (cas: 90721-35-0) belongs to isoquinoline derivatives. Quinoline is a mancude organic heterobicyclic parent, an azaarene, an ortho-fused heteroarene and a member of isoquinolines. Lewis acid activation and nucleophilic attack can produce multiple regioisomers in quinolines and pyridines; isoquinolines generally only undergo attack at the 1-position.Electric Literature of C9H7BrN2
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem