Sit, Sing-Yuen et al. published their research in Bioorganic & Medicinal Chemistry in 2004 | CAS: 90721-35-0

5-Bromoisoquinolin-8-amine (cas: 90721-35-0) belongs to isoquinoline derivatives. Quinoline and its derivatives are widely used as fungicides, biological agents, antibiotics, alkaloids, dyes, rubber chemicals and flavoring agents. The discovery of chloroquine, the most well-known drug containing this stent, has helped bring about decades of malaria control and treatment.Formula: C9H7BrN2

Synthesis and SAR exploration of dinapsoline analogues was written by Sit, Sing-Yuen;Xie, Kai;Jacutin-Porte, Swanee;Boy, Kenneth M.;Seanz, James;Taber, Matthew T.;Gulwadi, Amit G.;Korpinen, Carolyn D.;Burris, Kevin D.;Molski, Thaddeus F.;Ryan, Elaine;Xu, Cen;Verdoorn, Todd;Johnson, Graham;Nichols, David E.;Mailman, Richard B.. And the article was included in Bioorganic & Medicinal Chemistry in 2004.Formula: C9H7BrN2 This article mentions the following:

Dinapsoline is a full D1 dopamine receptor agonist that produces robust rotational activity in the unilateral 6-OHDA rat model. This compound is orally active, and shows a low tendency to cause tolerance in rat models. The active enantiomer was determined to have the S-(+) configuration, and the opposite enantiomer is essentially devoid of biol. activity. Taken together, dinapsoline has significant metabolic and pharmacol. advantages over previous D1 agonists. In an attempt to define the structure-activity relationships (SARs) and to map out the key elements surrounding the unique structure of dinapsoline, core analogs and substitution analogs of the parent tetracyclic condensed ring structure were prepared Based on a recently developed synthesis of dinapsoline and its enantiomers, both core and substitution analogs on all four rings (A, B’, C and D ring) of dinapsoline were synthesized. It was found that affinity for both D1 and D2 receptors was decreased by most substituents on the A, B’, and C rings, whereas D ring substitutions preserved much of the dopamine receptor binding activity. In the experiment, the researchers used many compounds, for example, 5-Bromoisoquinolin-8-amine (cas: 90721-35-0Formula: C9H7BrN2).

5-Bromoisoquinolin-8-amine (cas: 90721-35-0) belongs to isoquinoline derivatives. Quinoline and its derivatives are widely used as fungicides, biological agents, antibiotics, alkaloids, dyes, rubber chemicals and flavoring agents. The discovery of chloroquine, the most well-known drug containing this stent, has helped bring about decades of malaria control and treatment.Formula: C9H7BrN2

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem