Design, Synthesis, and Structure-Activity Relationships of Highly Potent 5-HT3 Receptor Ligands was written by Verheij, Mark H. P.;Thompson, Andrew J.;van Muijlwijk-Koezen, Jacqueline E.;Lummis, Sarah C. R.;Leurs, Rob;de Esch, Iwan J. P.. And the article was included in Journal of Medicinal Chemistry in 2012.Application In Synthesis of 3-Chloroisoquinolin-1-amine This article mentions the following:
Quinazoline and quinoline analogs of diazepanylquinazolinamine I, found as a hit fragment for inhibition of the serotonin 5-HT3a receptor, were prepared and tested as ligands for the 5-HT3a receptor. Several high affinity ligands were found, of which II showed the highest affinity (pKi > 10) for the 5-HT3 receptor. The observed structure-activity relationship is in agreement with established pharmacophore models for 5-HT3 ligands and was used for ligand-receptor binding mode prediction using homol. modeling and in silico docking approaches. In the experiment, the researchers used many compounds, for example, 3-Chloroisoquinolin-1-amine (cas: 7574-67-6Application In Synthesis of 3-Chloroisoquinolin-1-amine).
3-Chloroisoquinolin-1-amine (cas: 7574-67-6) belongs to isoquinoline derivatives. Quinoline is a mancude organic heterobicyclic parent, an azaarene, an ortho-fused heteroarene and a member of isoquinolines. They are also used to make oil-soluble dyes, food colorants, pharmaceuticals, pH indicators and other organic compounds. Application In Synthesis of 3-Chloroisoquinolin-1-amine
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem