Real-Time Monitoring of Solid-Liquid Slurries: Optimized Synthesis of Tetrabenazine was written by Sato, Yusuke;Liu, Junliang;Kukor, Andrew J.;Culhane, Jeffrey C.;Tucker, John L.;Kucera, David J.;Cochran, Brian M.;Hein, Jason E.. And the article was included in Journal of Organic Chemistry in 2021.Computed Properties of C19H27NO3 This article mentions the following:
Solid-liquid slurries are vital and increasingly prevalent in the pharmaceutical and chem. industries. Despite the importance of these heterogeneous systems, process control and optimization are fundamentally hindered by a lack of compatible real-time anal. techniques. We present herein an online HPLC monitoring platform enabling access to real-time compositional information on slurries. We demonstrate the system by investigating the heterogeneous synthesis reaction of tetrabenazine. Furthermore, we integrated our online HPLC platform with the orthogonal monitoring techniques of a pH probe and a microscopic imaging probe to provide addnl. mechanistic insight. These combined insights enable the optimization of tetrabenazine synthesis in terms of reaction time, byproduct formation, and diastereomeric purity of the final product. In the experiment, the researchers used many compounds, for example, Tetrabenazine (+)- (cas: 1026016-83-0Computed Properties of C19H27NO3).
Tetrabenazine (+)- (cas: 1026016-83-0) belongs to isoquinoline derivatives. Quinoline and isoquinoline skeletons are among the most attractive frameworks with a wide range of biological and pharmacological activities. Other industrial applications include their use as corrosion inhibitors, preservatives, and as solvents for resins and terpenes.Computed Properties of C19H27NO3
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem