Effect of berberine on serum cholesterol and pentobarbitone sleeping time in rats was written by Vad, B. G.;Raman, P. H.;Deshmukh, V. K.. And the article was included in Indian Journal of Pharmacy in 1971.SDS of cas: 316-41-6 This article mentions the following:
Oral and i.m. administration of berberine sulfate decreased serum cholesterol levels and increased duration of pentobarbitone sleeping time in rats. Male rats were divided into 2 groups of 15 each and average initial weight, serum cholesterol level, and pentobarbitone sleeping time (pentobarbitone Na, 40 mg/kg i.p.) were recorded. The initial average serum cholesterol level was 56 mg % and pentobarbitone sleeping time was 90 min. After 3 weeks of daily administration of berberine, the serum cholesterol levels were lowered by 35% and 25% and the pentobarbitone sleeping time was prolonged by 41% and 35% in the 20 mg/kg oral and 2 mg/kg i.m. groups, resp. In the experiment, the researchers used many compounds, for example, 9,10-Dimethoxy-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ium sulfate(2:1) (cas: 316-41-6SDS of cas: 316-41-6).
9,10-Dimethoxy-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ium sulfate(2:1) (cas: 316-41-6) belongs to isoquinoline derivatives. Quinoline is a mancude organic heterobicyclic parent, an azaarene, an ortho-fused heteroarene and a member of isoquinolines. They are also used to make oil-soluble dyes, food colorants, pharmaceuticals, pH indicators and other organic compounds. SDS of cas: 316-41-6
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem