2-(Pyrrolidin-1-yl)ethyl-3,4-dihydroisoquinolin-1(2H)-one Derivatives as Potent and Selective Histamine-3 Receptor Antagonists was written by Zhou, Dahui;Gross, Jonathan L.;Adedoyin, Adedayo B.;Aschmies, Suzan B.;Brennan, Julie;Bowlby, Mark;Di, Li;Kubek, Katie;Platt, Brian J.;Wang, Zheng;Zhang, Guoming;Brandon, Nicholas;Comery, Thomas A.;Robichaud, Albert J.. And the article was included in Journal of Medicinal Chemistry in 2012.Recommanded Product: 1109230-25-2 This article mentions the following:
On the basis of the previously reported benzimidazole 1,3′-bipyrrolidine benzamides, a new class of 48 2-(pyrrolidin-1-yl)ethyl-3,4-dihydroisoquinolin-1(2H)-one derivatives were synthesized and evaluated as potent H3 receptor antagonists. In particular, I exhibited potent in vitro binding and functional activities at the H3 receptor, good selectivities against other neurotransmitter receptors and ion channels, acceptable pharmacokinetic properties, and a favorable in vivo profile. In the experiment, the researchers used many compounds, for example, 5-Bromo-3,4-dihydroisoquinolin-1(2H)-one (cas: 1109230-25-2Recommanded Product: 1109230-25-2).
5-Bromo-3,4-dihydroisoquinolin-1(2H)-one (cas: 1109230-25-2) belongs to isoquinoline derivatives. Quinoline and its derivatives are widely used as fungicides, biological agents, antibiotics, alkaloids, dyes, rubber chemicals and flavoring agents. Most traditional methods of generating isoquinoline do so via oxidative aromatization of dihydro- or tetrahydro-isoquinolines, usually offering some environmental or economic advantage.Recommanded Product: 1109230-25-2
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem