Fluorescence “On-Off” chemical sensor for ultrasensitive detection of Al3+ in live cell was written by Zhu, Jinli;Lu, Linxia;Wang, Miao;Sun, Tongming;Huang, Yang;Wang, Chunxian;Bao, Wenyan;Wang, Minmin;Zou, Fengxia;Tang, Yanfeng. And the article was included in Tetrahedron Letters in 2020.Computed Properties of C10H7NO2 This article mentions the following:
An efficient fluorescent probe, 3, 3-bis(4-hydroxyphenyl)-2-benzofuran-1-one-isoquinoline-1-carbohydrazide hydrazine (L, I), has been prepared for the selective sensing of Al3+ in DMSO-H2O (90:10, volume/volume) solution The 1:2 stoichiometry of L and Al3+ was determined from Job’s plot experiments and ESI-MS. The binding constants was observed as 7.106 x 1010 M-2, and the detection limit is 9.79 x 10-9 M. Moreover, the as-prepared probe shows high sensitivity to Al3+ both in acidic and neutral conditions. In addition, the as-prepared probe with good biol. compatibility shows effective imaging of Al3+ in living cells. In the experiment, the researchers used many compounds, for example, Isoquinoline-1-carboxylic acid (cas: 486-73-7Computed Properties of C10H7NO2).
Isoquinoline-1-carboxylic acid (cas: 486-73-7) belongs to isoquinoline derivatives. Quinoline and its derivatives are widely used as fungicides, biological agents, antibiotics, alkaloids, dyes, rubber chemicals and flavoring agents. The Pomeranz–Fritsch reaction provides a method for the preparation of isoquinoline. This reaction uses a benzaldehyde and aminoacetoaldehyde diethyl acetal, which in an acid medium react to form isoquinoline.Computed Properties of C10H7NO2
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem