A Palladium(0)-Catalyzed C4 Site-Selective C-H Difluoroalkylation of Isoquinolin-1(2H)-Ones was written by Zhu, You-Quan;Hui, Li-Wen;Zhang, Shi-Bo. And the article was included in Advanced Synthesis & Catalysis in 2021.HPLC of Formula: 491-30-5 This article mentions the following:
A palladium(0)-catalyzed C4 site-selective C-H difluoroalkylation of isoquinolin-1(2H)-ones with 2-bromo-2,2-difluoroacetate or 2-bromo-2,2-difluoroacetamides through a radical pathway afforded 2,2-difluoro-2-(1-oxo-1,2-dihydroisoquinolin-4-yl)acetates/acetamides I [R = Me, Et, Ph, etc.; R1 = H, CF2CO2Et, CF2C(O)-morpholin-4-yl, CF2C(O)NHCH2CO2Me; R2 = H, CF2CO2Et; R3 = H, 6-OMe, 7-Cl, etc.]. This method provided an efficient and convenient approach to install a difluoroacetate or a difluoroacetamide moiety into bioactive mols. Bioassay results showed that introduction of these difluorinated groups at C4 position was beneficial to improve their antiviral activity and compound I [R = 3,4-MeC6H3; R1 = H; R2 = CF2CO2Et; R3 = H] was found to exhibit similar antiviral activity with com. Ningnanmycin. In the experiment, the researchers used many compounds, for example, 1-Hydroxyisoquinoline (cas: 491-30-5HPLC of Formula: 491-30-5).
1-Hydroxyisoquinoline (cas: 491-30-5) belongs to isoquinoline derivatives. Isoquinoline is a structural isomer of quinoline, which have antiseptic, antipyretic and anti-cyclic properties, and can be used as antimalarial drugs and for the preparation of other antimalarial medicine. Other industrial applications include their use as corrosion inhibitors, preservatives, and as solvents for resins and terpenes.HPLC of Formula: 491-30-5
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem