Reactions of 1,2,3,4-tetrahydroisoquinoline derivatives with sulfur was written by Ajzert, K. Ilona;Takacs, Kalman. And the article was included in Liebigs Annalen der Chemie in 1987.Electric Literature of C15H13N This article mentions the following:
1,2,3,4-Tetrahydroisoquinolines react with sulfur in pyridine to give two different types of products, depending on the structure of the starting compounds 1-Substituted derivatives I [R = Me, Ph, CH2CN, 3,4-(MeO)2C6H3CH2; R1 = H, MeO; R2 = R3 = H] undergo partial dehydrogenation with formation of, the corresponding 3,4-dihydroisoquinolines I [R, R1 = same, R2R3 = bond]. 1,2,3,4-Tetrahydroisoquinolines I (R = R3 = H; R1 = H, MeO; R2 = H, Me, PhCH2) bearing no substituent in 1-position yield the 3,4-dihydro-1(2H)-isoquinolinethiones I [RR3 = (:S), R1, R2 = same]. In the experiment, the researchers used many compounds, for example, 1-Phenyl-3,4-dihydroisoquinoline (cas: 52250-50-7Electric Literature of C15H13N).
1-Phenyl-3,4-dihydroisoquinoline (cas: 52250-50-7) belongs to isoquinoline derivatives. Being an analog of pyridine, isoquinoline is a weak base, with a pKa of 5.14. The discovery of chloroquine, the most well-known drug containing this stent, has helped bring about decades of malaria control and treatment.Electric Literature of C15H13N
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem