Palladium-catalysed cascades triggered by dehydrogenation of secondary or tertiary amines: access to bridged- and fused-ring heterocycles was written by Grigg, Ronald;Somasunderam, Anoma;Sridharan, Visuvanathar;Keep, Ann. And the article was included in Synlett in 2009.Quality Control of Methyl isoquinoline-3-carboxylate This article mentions the following:
Palladium-catalyzed cascades triggered by dehydrogenation of secondary or tertiary amines and trapping the intermediate imines with cycloadditions and Mannich reactions result in a range of bridged- and fused-ring nitrogen heterocyclic motifs in moderate to good yields. In the experiment, the researchers used many compounds, for example, Methyl isoquinoline-3-carboxylate (cas: 27104-73-0Quality Control of Methyl isoquinoline-3-carboxylate).
Methyl isoquinoline-3-carboxylate (cas: 27104-73-0) belongs to isoquinoline derivatives. Isoquinoline is a structural isomer of quinoline, which have antiseptic, antipyretic and anti-cyclic properties, and can be used as antimalarial drugs and for the preparation of other antimalarial medicine. The discovery of chloroquine, the most well-known drug containing this stent, has helped bring about decades of malaria control and treatment.Quality Control of Methyl isoquinoline-3-carboxylate
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem