Iterative Arylation of Amino Acids and Aliphatic Amines via 未-C(sp3)-H Activation: Experimental and Computational Exploration was written by Guin, Srimanta;Dolui, Pravas;Zhang, Xinglong;Paul, Satyadip;Singh, Vikas Kumar;Pradhan, Sukumar;Chandrashekar, Hediyala B.;Anjana, S. S.;Paton, Robert S.;Maiti, Debabrata. And the article was included in Angewandte Chemie, International Edition in 2019.Category: isoquinoline This article mentions the following:
Directed C-H functionalization has been realized as a complementary tool to the traditional approaches for a straightforward access of non-proteinogenic amino acids; albeit such a process is restricted mostly up to the 纬-position. In the present work, we demonstrate the diverse (hetero)arylation of amino acids and analogous aliphatic amines selectively at the remote 未-position by tuning the reactivity controlled by ligands. An organopalladium 未-C(sp3)-H activated intermediate has been isolated and crystallog. characterized. Mechanistic investigations carried out exptl. in conjunction with computational studies shed light on the difference in the mechanistic picture depending on the substrate structure. In the experiment, the researchers used many compounds, for example, 1-Hydroxyisoquinoline (cas: 491-30-5Category: isoquinoline).
1-Hydroxyisoquinoline (cas: 491-30-5) belongs to isoquinoline derivatives. Although isoquinoline derivatives can be synthesized by several methods, relatively few direct methods deliver the unsubstituted isoquinoline. The discovery of chloroquine, the most well-known drug containing this stent, has helped bring about decades of malaria control and treatment.Category: isoquinoline
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem