Asymmetric 1,4-Michael Addition in Aqueous Medium Using Hydrophobic Chiral Organocatalysts was written by Mahato, Chandan K.;Mukherjee, Sayan;Kundu, Mrinalkanti;Vallapure, Virbhadra P.;Pramanik, Animesh. And the article was included in Journal of Organic Chemistry in 2021.Computed Properties of C9H7NO This article mentions the following:
Organic transformations exclusively in water as an environmentally friendly and safe medium have drawn significant interest in the recent years. Moreover, transition metal-free synthesis of enantiopure mols. in water will have a great deal of attention as the system will mimic the natural enzymic reactions. In this work, a new set of proline-derived hydrophobic organocatalysts have been synthesized and utilized for asym. Michael reactions in water as the sole reaction medium. Among the various catalysts screened, the catalyst 1 is indeed efficient for stereoselective 1,4-conjugated Michael additions (dr: >97:3, ee up to >99.9%) resulting in high chem. yields (up to 95%) in a very short reaction time (1 h) at room temperature This methodol. provides a robust, green, and convenient protocol and can thus be an important addition to the arsenal of the asym. Michael addition reaction. Upon successful implementation, the present strategy also led to the formation of an optically active octahydroindole, the key component found in many natural products. In the experiment, the researchers used many compounds, for example, 1-Hydroxyisoquinoline (cas: 491-30-5Computed Properties of C9H7NO).
1-Hydroxyisoquinoline (cas: 491-30-5) belongs to isoquinoline derivatives. Being an analog of pyridine, isoquinoline is a weak base, with a pKa of 5.14. The discovery of chloroquine, the most well-known drug containing this stent, has helped bring about decades of malaria control and treatment.Computed Properties of C9H7NO
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem