Enantioselective Intermolecular [2 + 2] Photocycloaddition Reactions of 2(1H)-Quinolones Induced by Visible Light Irradiation was written by Troester, Andreas;Alonso, Rafael;Bauer, Andreas;Bach, Thorsten. And the article was included in Journal of the American Chemical Society in 2016.Product Details of 491-30-5 This article mentions the following:
In the presence of a chiral thioxanthone catalyst (10 mol %) the title compounds underwent a clean intermol. [2+2] photocycloaddition with electron-deficient olefins at 位 = 419 nm. The reactions not only proceeded with excellent regio- and diastereoselectivity but also delivered the resp. cyclobutane products with significant enantiomeric excess (up to 95% ee). Key to the success of the reactions is a two-point hydrogen bonding between quinolone and catalyst enabling efficient energy transfer and high enantioface differentiation. Preliminary work indicated that solar irradiation can be used for this process and that the substrate scope can be further expanded to isoquinolones. In the experiment, the researchers used many compounds, for example, 1-Hydroxyisoquinoline (cas: 491-30-5Product Details of 491-30-5).
1-Hydroxyisoquinoline (cas: 491-30-5) belongs to isoquinoline derivatives. Quinoline is a catabolite of tryptophan, the basic structure of some antihypertensive drugs, such as the peripheral vasodilators prazosin and doxazosin. Most traditional methods of generating isoquinoline do so via oxidative aromatization of dihydro- or tetrahydro-isoquinolines, usually offering some environmental or economic advantage.Product Details of 491-30-5
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem